Understanding how molecules involved in healing produce pain relief in osteoarthritis
Disease - Osteoarthritis
Lead applicant - Professor Victoria Chapman
Organisation - University of Nottingham
Type of grant - Special strategic award
Status of grant - Approved
Amount of the original award - £318,495.50
Start date - 01 March 2022
Reference - TBC
What are the aims of this research?
This research aims to better understand how molecules involved in healing produce pain relief in osteoarthritis.
Why is this research important?
There is currently no cure for osteoarthritis and drug treatments are often ineffective at reducing the pain associated with it. To develop new drug treatments, it is necessary to better understand the mechanisms behind osteoarthritis pain. Previous research has shown that a naturally occurring molecule produced in healing is able to reduce pain, and people with painful osteoarthritis had lower levels of this molecule in their blood. It is thought that when these molecules are broken down by the body, they are also able to affect pain, by reducing the production of other molecules that cause pain. The researchers will study blood samples from people with arthritis and look at the effects of this molecule in mice to understand how it reduces pain in order to find new and effective ways to treat pain associated with arthritis.
How will these findings benefit patients?
This study could help researchers understand how these molecules are involved in reducing pain, in order to produce effective treatments which will be able to target these effects.