Defining the role of cell migration in the initiation and regulation of pathogenesis in inflammatory arthritis
Disease - Rheumatoid arthritis
Lead applicant - Professor Paul Garside
Organisation - University of Glasgow
Type of grant - Programme Grant Full application
Status of grant - Active
Amount of the original award - £778,900
Start date - 1 February 2013
Reference - 19788
What are the aims of this research?
The aims of this research are to show how immune system cells move in and out of organs where they are first switched on (lymph nodes or 'glands') and then make their way to attack target tissues (joints). We will then determine the molecules these cells use to 'find' and then 'talk' to each other and what it is about these 'conversations' that allows the development of arthritis.
Why is this research important?
This research will underpin the future development and targeting of new medicines that modify the cell movement and interactions underlying the initial development of rheumatoid arthritis. Should our studies show how cells get to the joint in the first place, and even more importantly find out where they are switched on in the first place, our work offers the promise of prevention based medicines in future.
How will the findings benefit patients?
These findings will inform the development medicines to treat rheumatoid arthritis earlier and in a more targeted fashion, increasing the possibility of drug-free remission and cure.